The Jerusalem Girls’ College was established by the Anglican Jerusalem and East Mission after World War I, Initially called the British High School and Training College it was renamed the Jerusalem Girls' College in 1923. Its first headmistress was Mabel Warburton.
The college was located at two different sites:. It is unclear where the initial site was; one source suggests it was the site of the St. Mary's Home in the Anglican compound. However, another source says it was on the site of a pre-war German institution.
Later, it was located at a site in Rehavia